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KMID : 0604520190450010019
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Journal of the Society of Cosmetic Scientists of Korea
2019 Volume.45 No. 1 p.19 ~ p.25
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Effect of Defatted Torreya nucifera Seed Extract on the Cross-linking of Advanced Glycation End Products to Collagen
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Son Da-Hee
Kim Min-Kyung
Park Deok-Hoon
Jung Eun-Sun
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Abstract
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Advanced glycation end products (AGEs) are final products formed by glycation reaction between reducing sugars and proteins, lipids or nucleic acids. These AGEs are related to progress of skin aging. In this study, we evaluate anti-aging activity of Defatted Torreya nucifera seed extract (DTSE) through antioxidant, anti-glycation, anti-elastase and inhibitory and breaking activity on the cross-linking of AGEs to collagen assay. Results showed that DTSE contained polyphenols and flavonoids. The IC50 values of 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical and 2,2'-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity were 16.4 μg (Dried materials, DM)/mL and 16.7 μg DM/mL, respectively. DTSE also inhibited the formation of AGEs, elastase activity and cross-linking of AGEs to collagen as well as broke existing cross-linking of AGEs to collagen in a dose-dependent manner. Consequently, our findings suggest that DTSE could be useful as a cosmetic material with anti-aging activity.
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KEYWORD
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Torreya nucifera, AGEs, anti-aging, antioxidant, anti-glycation
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